Genetic lesions within the 3a gene of SARS-CoV
Identifieur interne : 004821 ( Main/Exploration ); précédent : 004820; suivant : 004822Genetic lesions within the 3a gene of SARS-CoV
Auteurs : Timothy Hp Tan [Singapour] ; Timothy Barkham [Singapour] ; Burtram C. Fielding [Singapour] ; Chih-Fong Chou [Singapour] ; Shuo Shen [Singapour] ; Seng Gee Lim [Singapour] ; Wanjin Hong [Singapour] ; Yee-Joo Tan [Singapour]Source :
- Virology Journal [ 1743-422X ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- génétique : ARN viral, Protéines virales, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Humains, Mutation avec décalage du cadre de lecture.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : RNA, Viral, Viral Proteins.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Frameshift Mutation, Humans.
Abstract
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
The online version of this article (doi:10.1186/1743-422X-2-51) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1743-422X-2-51
PubMed: 15963240
PubMed Central: 1183252
Affiliations:
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Le document en format XML
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Tan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.418812.6</institution-id><institution>Institute of Molecular and Cell Biology,</institution></institution-wrap>College Station, 61 Biopolis Drive, 138673 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>College Station, 61 Biopolis Drive</wicri:regionArea><wicri:noRegion>61 Biopolis Drive</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Frameshift Mutation</term><term>Humans</term><term>RNA, Viral (genetics)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Humains</term><term>Mutation avec décalage du cadre de lecture</term><term>Protéines virales (génétique)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Frameshift Mutation</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Mutation avec décalage du cadre de lecture</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1743-422X-2-51) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vega, Vb" uniqKey="Vega V">VB Vega</name></author><author><name sortKey="Ruan, Y" uniqKey="Ruan Y">Y Ruan</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Lee, Wh" uniqKey="Lee W">WH Lee</name></author><author><name sortKey="Wei, Cl" uniqKey="Wei C">CL Wei</name></author><author><name sortKey="Se Thoe, Sy" uniqKey="Se Thoe S">SY Se-Thoe</name></author><author><name sortKey="Tang, Kf" uniqKey="Tang K">KF Tang</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Kolatkar, Pr" uniqKey="Kolatkar P">PR Kolatkar</name></author><author><name sortKey="Ooi, Ee" uniqKey="Ooi E">EE Ooi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Zhao, W" uniqKey="Zhao W">W Zhao</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name></author><author><name sortKey="Gu, C" uniqKey="Gu C">C Gu</name></author><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Zheng, C" uniqKey="Zheng C">C 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uniqKey="Hong W">W Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Yj" uniqKey="Tan Y">YJ Tan</name></author><author><name sortKey="Teng, E" uniqKey="Teng E">E Teng</name></author><author><name sortKey="Shen, S" uniqKey="Shen S">S Shen</name></author><author><name sortKey="Tan, Th" uniqKey="Tan T">TH Tan</name></author><author><name sortKey="Goh, Py" uniqKey="Goh P">PY Goh</name></author><author><name sortKey="Fielding, Bc" uniqKey="Fielding B">BC Fielding</name></author><author><name sortKey="Ooi, Ee" uniqKey="Ooi E">EE Ooi</name></author><author><name sortKey="Tan, Hc" uniqKey="Tan H">HC Tan</name></author><author><name sortKey="Lim, Sg" uniqKey="Lim S">SG Lim</name></author><author><name sortKey="Hong, W" uniqKey="Hong W">W Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, R" uniqKey="Zeng R">R Zeng</name></author><author><name sortKey="Yang, Rf" uniqKey="Yang R">RF Yang</name></author><author><name sortKey="Shi, Md" uniqKey="Shi M">MD Shi</name></author><author><name sortKey="Jiang, Mr" uniqKey="Jiang M">MR Jiang</name></author><author><name sortKey="Xie, Yh" uniqKey="Xie Y">YH Xie</name></author><author><name sortKey="Ruan, Hq" uniqKey="Ruan H">HQ Ruan</name></author><author><name sortKey="Jiang, Xs" uniqKey="Jiang X">XS Jiang</name></author><author><name sortKey="Shi, L" uniqKey="Shi L">L Shi</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Wang, Fs" uniqKey="Wang F">FS Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, N" uniqKey="Ito N">N Ito</name></author><author><name sortKey="Mossel, 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sortKey="Charpentier, N" uniqKey="Charpentier N">N Charpentier</name></author><author><name sortKey="Bracho, A" uniqKey="Bracho A">A Bracho</name></author><author><name sortKey="Moya, A" uniqKey="Moya A">A Moya</name></author><author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Barreno, B" uniqKey="Garcia Barreno B">B Garcia-Barreno</name></author><author><name sortKey="Delgado, T" uniqKey="Delgado T">T Delgado</name></author><author><name sortKey="Melero, Ja" uniqKey="Melero J">JA Melero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medina, M" uniqKey="Medina M">M Medina</name></author><author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name></author><author><name sortKey="Brangwyn, Jk" uniqKey="Brangwyn J">JK Brangwyn</name></author><author><name sortKey="Belsham, Gj" uniqKey="Belsham G">GJ Belsham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Yj" uniqKey="Tan Y">YJ Tan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Tan, Timothy Hp" sort="Tan, Timothy Hp" uniqKey="Tan T" first="Timothy Hp" last="Tan">Timothy Hp Tan</name></noRegion><name sortKey="Barkham, Timothy" sort="Barkham, Timothy" uniqKey="Barkham T" first="Timothy" last="Barkham">Timothy Barkham</name><name sortKey="Chou, Chih Fong" sort="Chou, Chih Fong" uniqKey="Chou C" first="Chih-Fong" last="Chou">Chih-Fong Chou</name><name sortKey="Fielding, Burtram C" sort="Fielding, Burtram C" uniqKey="Fielding B" first="Burtram C" last="Fielding">Burtram C. Fielding</name><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= SrasV1
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|étape= Exploration
|type= RBID
|clé= PMC:1183252
|texte= Genetic lesions within the 3a gene of SARS-CoV
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